Publications

2018

(27) Ciulla, D., Jorgenson M., Giner J., Callahan BP* “Chemical bypass of general base catalysis in hedgehog protein cholesterolysis using a hyper-reactive substrate.” J. Am. Chem. Soc. (cover image) 2018 140, 916-918.

2017

(26) Li A., Yadav R., White, J., Herroon, M., Callahan, BP, Podgorski, I., Turro, C., Scott, Emily E., Kodanko, J. “Illuminating Inhibition of Cytochrome P450 17A1: Targeting Prostate Cancer.”  ChemComm. 2017 53, 3673-3676.

2016

(25) Bordeau B.M., Ciulla D.A., Callahan BP * “Hedgehog proteins consume steroidal CYP17A1 antagonists: Potential therapeutic significance in advanced prostate cancer.” ChemMedChem. 2016 11, 1983–1986. (Selected for virtual issue, MedChem in USA)

(24) Xie J., Owen T., Xia K., Callahan B, Wang C. “A single aspartate controls two steps in hedgehog protein autoprocessing.”  J. Am. Chem. Soc. 2016 138, 10806-9.

2015

(23) Callahan BP *, Wang C.  “Hedgehog cholesterolysis: specialized gatekeeper to oncogenic signaling.” Cancers (Basel). 2015 7, 2037-53.

(22) Owen T.S., Ngoje G., Lageman T., Bordeau B., Belfort M, Callahan BP*.  “Förster resonance energy transfer-based cholesterolysis assay identifies a novel hedgehog inhibitor.” Anal. Biochem. 2015 488, 1-5.

(21) Xie J, Owen TS, Xia K, Vikram-Singh A, Tou E, Li L, Wan LQ, Callahan BP, Wang C. “Zinc inhibits hedgehog autoprocessing: implications for a novel pathway in diseases” J. Biol. Chem 2015 290: 11591-600.

(20) Owen TS, Xie J, Laraway B, Ngoje G, Wang C, Callahan BP*.  “Active site targeting of hedgehog precursor protein with phenylarsine oxide” ChemBioChem. 2015 16:55-8.

2014

(19) Callahan BP*, Belfort M*.  “Branching out of the intein active site in protein splicing” Proc. Nat’l Acad. Sci. 2014 111, 8323-4.

(18) Xie J, Du Z, Callahan B., Belfort M, Wang C. (1)H, (13)C, and (15)N NMR assignments of a Drosophila Hedgehog autoprocessing domain. Biomol. NMR Assign. 2014 8, 279-81.

Pre-2013

POST-Doctoral Trainee

(17) Dearden AK, Callahan B., Roey PV, Li Z, Kumar U, Belfort M, Nayak SK. A conserved threonine spring-loads precursor for intein splicing.  Protein Sci. 2013 22, 557-63.

(16) Callahan BP*, Stanger M, Belfort M. A redox trap to augment the intein toolbox. Biotechnol Bioeng. 2013 110, 1565-73.

(15) Callahan BP, Topilina, N., Stanger M., Van Roey, P., Belfort M. Structure of a catalytically competent intein caught in a redox trap with functional and biological implications. Nat. Struct. Mol. Biol. 2011 18, 630-3.

(14) Zhang L, Zheng, Y, Callahan B, Belfort M., Liu, Y. Cisplatin as a protein splicing inhibitor suggesting inteins as therapeutic targets in mycobacteria J. Biol. Chem. 2011 286, 1277-82 (Highlighted in Nature Chemical Biology).

(13) Callahan BP, Stanger M., Belfort M. Protease activation of split green fluorescent protein ChemBioChem  2010 11, 2259-63.

(12) Callahan B, Nguyen K., Gormley A., Valdes K., Caplow M., Crossman D.K., Steyn A.J.C., Eisele L., Derbyshire K. Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA.  J. Bacteriology. 2010 192, 326-35.

(11) Amitai G., Callahan BP, Stanger M., Belfort G., Belfort M. Modulation of intein activity by its neighboring extein substrates.. Proc. Natl. Acad. Sci. 2009 106, 11005-10.

(10) Coros A., Callahan B, Battaglioli E., Derbyshire K.M. The specialized secretory apparatus ESX-1 is essential for DNA transfer in Mycobacterium smegmatisMol. Microbiol. 2008 69, 794-808.

Graduate Student

(9) Callahan BP *, Miller BG*. OMP decarboxylase—An enigma persists. Bioorg. Chem. 2007 35, 465-9.

(8) Callahan BP, Lomino, J.V., Wolfenden R. Nanomolar inhibition of the enterobactin biosynthesis enzyme, EntE: Synthesis, substituent effects, and additivity. Bioorg. Med. Chem. Lett. 2006 16, 3802-05.

(7) Callahan BP,  Bell,  A.F.,  Tonge  P.,  Wolfenden  R.  A Raman-active competitive inhibitor of OMP decarboxylase Bioorg. Chem. 2006 34, 59-65.

(6) Callahan B.P., Yaun, Y., Wolfenden, R. The Burden Borne by Urease J. Am. Chem. Soc. 2005 127, 10828-9. (Highlighted in Science)

(5) Callahan BP,  Wolfenden,  R.  OMP  Decarboxylase:  an  Experimental  Test  of  Ground  State Destabilization of the Enzyme-Substrate Complex  J. Am. Chem. Soc  2004 126, 14698-9. (Highlighted in Faculty of 1000)

(4) Callahan BP, Wolfenden, R. Charge Development in the Transition State for Decarboxylations in Water: Spontaneous and Acetone-Catalyzed Decarboxylation of Aminomalonate J. Am. Chem. Soc. 2004 126, 4514-15. (Highlighted in Faculty of 1000)

(3) Callahan BP, Wolfenden, R. Migration of Methyl Groups between Aliphatic Amines in Water J. Am. Chem. Soc. 2003 125, 310-11.

Laboratory Technician

(2)  Wei C., Callahan BP, Turner M.J., Willis R.A., Lord E.M., Barth R.K., Frelinger J.G. Regulation of human prostate-specific antigen gene expression in transgenic mice: evidence for an enhancer between the PSA and human glandular kallikrein-1 genes. Int J Mol Med. 1998 2, 487-96.

(1) Willis R.A., Wei C., Turner M.J., Callahan BP, Pugh A.E., Barth R.K., Lord E.M., Frelinger J.G. A transgenic strategy for analyzing the regulatory regions of the human prostate-specific antigen gene: potential applications for the treatment of prostate cancer (Review). Int J Mol Med. 1998 1, 379-86.